Blair D. Siegfried
306 Plant Industry Bldg.
(402) 472-8714
bsiegfried1@unl.edu

 

 

 

 

Entomology 820

Insecticide Toxicology

Outline of Lecture Topics

 

Introduction to Toxicology and Pesticides                                                        

Exposure and Evaluation of Toxicity

Physiochemical Properties and Residue Analysis

Chemical Classification of Insecticides                                                            

Toxicodynamics I (Penetration through Biological Membranes)                 

Toxicodynamics II (Phase 1 Metabolism)                                                         

Toxicodynamics II (Extramicrosomal Phase 1 Metabolism)

Toxicodynamics III (Phase II Metabolism; Conjugation)

EXAM 1

Neurophysiology I                                                                                                 

Neurophysiology II

Organochlorines                                                                                                   

Anticholinesterases I                                                                                            

Anticholinesterases II                                                                                      

Botanicals

Pyrethroids

Metabolic Inhibitors and Synergists

EXAM 2

Microbials

Transgenics and Biotechnology

Novel Chemistries

Growth Regulators                                                                                                 

Insecticide Resistance I

Insecticide Resistance II                                                                                  

Environmental Toxicology of Insecticides                                                   

Pesticide Regulations and Human Health

EXAM 3

 

General Information

 

Exams:  All exams are cumulative. Each exam will emphasize the material covered since the last exam, but all material is fair game. These exams will be comprised primarily of short answer essay questions. Questions are designed to force students to try and solve problems based on the material presented in lectures. A portion of each exam is open book so that any material available to the students can be used to assist in answering questions, although it is a requirement that each student work independently on the exams.

 

Review Paper:  Each student shall prepare a review paper equivalent to about 10 double-spaced typewritten pages that summarizes the literature on a toxicological problem of interest to the student. Topics should be approved by the instructor. Grading for the review paper will consist of 50 points for writing style and 50 points for content. A final copy of the paper is due at the end of the semester. 

 

Grades:         Grades will be based upon percentages of total points:

                        Exam 1                                  100 points

                        Exam 2                                  100

                        Exam 3                                  100

                        Review Paper                       100

 

                        Total                                      400

 

Grades will not be scaled with 90-100  = A; 80-89 = B; 70-79 = C; etc.

 

Readings: There are relatively few general textbooks on insecticide toxicology, and much of the information for lectures has been obtained from a variety of sources. The better texts are outdated and more importantly out of print. Therefore, most lecture material is available through the lecture notes provided at the course blackboard site. Suggested readings will also be made available for students to gain more information on areas of particular interest or on certain concepts that were not completely understood from lecture notes. These readings will be available at the UNL Libraries Electronic Reserves. I will be glad to respond to individual questions, but ask that these questions be posted to Blackboard site so that all students can benefit from the interactions.